PPM1L

Across TCGA patient cohorts, PPM1L mutation is significantly associated with the RNA expression of many other genes, with 855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPM1L-associated genes across cancer lineages are ADIPOR1P2, MRPS21P7, and CTBP2P9. Each is linked with PPM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PPM1L-to-partner and partner-to-PPM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOR1P2 grouped by PPM1L-low versus PPM1L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPM1L→partner) and Y-score (partner→PPM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ADIPOR1P2 →	+0.113	+4.642	<.001	.004	3	2
BLCA	MRPS21P7 →	+0.148	+4.788	<.001	.006	3	2
READ	CTBP2P9 →	+0.042	+6.257	<.001	.001	3	2
COAD	IGHVIV-44-1 →	+0.230	+3.343	<.001	.007	3	2
READ	MIR5089 →	+0.473	+5.653	<.001	.003	3	2
BLCA	RNY4P14 →	+0.317	+5.147	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

ADIPOR1P2 by PPM1L expression — BLCA

Explore this box plot interactively →