immunoglobulin heavy variable (IV)-44-1 (pseudogene)Genealiases: (IV)-44 · 4-44.1P · IGHVIV441
Q-omics provides the consensus-scored IGHVIV-44-1 profile across patient tissues and cancer cell-line models. IGHVIV-44-1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, IGHVIV-44-1 is differentially expressed in 2, with the highest sampling consensus in READ. Additionally, IGHVIV-44-1 RNA expression shows 7,597 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight LUSC, READ, and TGCT as cancer lineages where IGHVIV-44-1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGHVIV-44-1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGHVIV-44-1 survival associations across molecular data types. IGHVIV-44-1 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGHVIV-44-1 RNA expression–survival associations across cancer types. High IGHVIV-44-1 expression shows unfavorable associations in LUSC, OV, COAD and LAML, but favorable associations in BLCA and HNSC. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify LUSC as the clearest survival context for IGHVIV-44-1 RNA expression.
This table summarizes IGHVIV-44-1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in READ for RNA.
This table ranks reproducible tumor–normal expression differences for IGHVIV-44-1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGHVIV-44-1 shows lower tumor expression in READ and COAD. The READ box plot shows higher IGHVIV-44-1 RNA expression in normal versus tumor tissue (log2 FC = −0.110, t-test p = .021).
This table shows molecular features associated with IGHVIV-44-1 in patient tissues and cancer cell lines. In patient samples, IGHVIV-44-1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
