IGHVIV-44-1

Across TCGA pan-cancer cohorts, IGHVIV-44-1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHVIV-44-1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGHVIV-44-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVIV-44-1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

LUSC, BLCA, and OV are the cancer types where IGHVIV-44-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	III,IV	0.255	0.604	.001	90	view →
BLCA	OS	Tertile	IV	0.887	0.560	.016	51	view →
OV	DFS	Tertile	III,IV	0.379	0.539	.018	48	view →
COAD	DFS	Tertile	III,IV	0.231	0.663	<.001	42	view →
LAML	DFS	Tertile	All	0.163	0.481	.035	36	view →
HNSC	DFS	Tertile	All	0.833	0.691	.012	33	view →
TGCT	OS	Tertile	II,III,IV	0.802	1.000	.040	18	view →
LUAD	DFS	Tertile	IV	0.140	0.603	.021	18	view →
STAD	OS	Tertile	All	0.447	0.592	.033	12	view →
SKCM	OS	Quartile	III,IV	0.572	0.311	.010	11	view →
GBM	OS	Tertile	All	0.086	0.415	.010	9	view →
THYM	DFS	Tertile	All	0.134	0.871	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHVIV-44-1–LUSC (OS)

Open the LUSC breakdown →