IGHVIV-44-1

Across TCGA pan-cancer cohorts, IGHVIV-44-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVIV-44-1’s most consistent transcriptional readouts.

The strongest signal is observed in rectum adenocarcinoma (READ), where IGHVIV-44-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVIV-44-1 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

READ and COAD are the cancer types where IGHVIV-44-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIV-44-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
READ	All	All	−0.110	.021	4	view →
COAD	All	All	−0.093	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVIV-44-1–READ

Open the READ breakdown →