PPM1L

Across TCGA pan-cancer cohorts, PPM1L RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PPM1L’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PPM1L RNA is repressed in tumor relative to normal tissue. In most cancer types PPM1L is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and HNSC are the cancer types where PPM1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPM1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	IV	−2.178	<.001	12	view →
THCA	All	IV	−2.312	<.001	10	view →
HNSC	Male	All	−1.094	<.001	10	view →
LIHC	All	All	+0.546	<.001	8	view →
READ	All	All	−1.251	<.001	7	view →
BRCA	All	III,IV	−0.978	<.001	6	view →
KIRP	Male	All	−0.921	<.001	6	view →
KICH	All	All	+1.130	<.001	5	view →
COAD	Female	All	−0.701	<.001	4	view →
LUAD	Female	All	−0.520	<.001	4	view →
KIRC	All	All	−0.347	.002	4	view →
STAD	Female	All	−1.418	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PPM1L–BLCA

Open the BLCA breakdown →