PPIF

Across TCGA patient cohorts, PPIF mutation is significantly associated with the RNA expression of many other genes, with 1,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPIF-associated genes across cancer lineages are RN7SL248P, MIR6803, and RPL23AP90. Each is linked with PPIF in more than 1 cancer types. Because this analysis shows association rather than direction, both PPIF-to-partner and partner-to-PPIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PPIF-low versus PPIF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPIF→partner) and Y-score (partner→PPIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.064	+3.219	<.001	.004	3	2
UCEC	MIR6803 →	+0.108	+4.308	<.001	.003	3	2
UCEC	RPL23AP90 →	+0.255	+1.878	.007	.006	3	1
UCEC	LINC01607 →	-0.923	-3.885	<.001	<.001	3	1
UCEC	POM121C →	+0.445	+2.609	<.001	.006	3	1
UCEC	DCP1A →	+0.732	+3.850	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,685 associations by consensus.

RN7SL248P by PPIF expression — UCEC

Explore this box plot interactively →