PPIF

Across TCGA pan-cancer cohorts, PPIF RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PPIF data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPIF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPIF expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

UVM, LUAD, and HNSC are the cancer types where PPIF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.356	0.886	<.001	110	view →
LUAD	DFS	Quartile	III,IV	0.168	0.417	<.001	78	view →
HNSC	DFS	Quartile	III,IV	0.170	0.502	.003	53	view →
LAML	DFS	Median	All	0.228	0.543	<.001	52	view →
LGG	DFS	Median	All	0.827	0.648	<.001	45	view →
UCEC	OS	Median	All	0.825	0.918	<.001	40	view →
KIRC	OS	Tertile	All	0.829	0.916	.006	35	view →
SKCM	OS	Median	All	0.277	0.410	<.001	34	view →
THYM	DFS	Median	All	0.632	0.968	.002	30	view →
THCA	OS	Median	II,III,IV	0.932	1.000	.014	23	view →
SARC	DFS	Median	All	0.541	0.677	.004	20	view →
ESCA	OS	Tertile	All	0.380	0.582	.006	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PPIF–UVM (OS)

Open the UVM breakdown →