PPIF

Across TCGA pan-cancer cohorts, PPIF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPIF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PPIF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPIF is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

KICH, COAD, and LUSC are the cancer types where PPIF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPIF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	+1.178	<.001	11	view →
COAD	Female	All	+0.979	<.001	10	view →
LUSC	All	III,IV	+2.201	<.001	9	view →
LUAD	All	III,IV	+1.266	<.001	9	view →
THCA	Male	III,IV	−1.205	<.001	9	view →
HNSC	Male	All	+0.943	<.001	8	view →
KIRC	Male	II,III,IV	−0.869	<.001	7	view →
UCEC	All	III,IV	+1.701	<.001	6	view →
BLCA	Male	All	+1.269	.002	6	view →
BRCA	All	All	+0.657	<.001	6	view →
STAD	Male	II,III,IV	+0.777	<.001	5	view →
KIRP	Female	All	+0.593	.017	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPIF–KICH

Open the KICH breakdown →