PPARGC1A

Across TCGA cell cohorts, PPARGC1A mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PPARGC1A-associated genes across cancer lineages are C10orf71, TRIM49B, and TMIGD1. Each is linked with PPARGC1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARGC1A-to-partner and partner-to-PPARGC1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf71 grouped by PPARGC1A-low versus PPARGC1A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARGC1A→partner) and Y-score (partner→PPARGC1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C10orf71 →	+0.009	+3.981	<.001	.001	3	1
CNS	TRIM49B →	+0.398	+3.459	<.001	.006	3	1
CNS	TMIGD1 →	+0.026	+3.584	<.001	.003	3	1
CNS	NCMAP →	+0.434	+4.300	<.001	.001	3	1
CNS	NBPF4 →	+0.316	+3.449	<.001	.004	3	1
CNS	MTRNR2L10 →	+0.008	+4.357	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

C10orf71 by PPARGC1A expression — CNS

Explore this box plot interactively →