PPARGC1A

Across TCGA pan-cancer cohorts, PPARGC1A RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PPARGC1A data layer compared with 11 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher PPARGC1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPARGC1A expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and UCEC are the cancer types where PPARGC1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.687	0.396	<.001	126	view →
KIRC	OS	Median	All	0.738	0.541	<.001	122	view →
UCEC	DFS	Tertile	II,III,IV	0.336	0.752	<.001	94	view →
ACC	OS	Tertile	All	0.889	0.385	<.001	92	view →
BLCA	OS	Tertile	II,III,IV	0.529	0.708	<.001	85	view →
LIHC	OS	Median	All	0.763	0.603	<.001	84	view →
KIRP	DFS	Quartile	All	0.946	0.746	<.001	51	view →
COAD	OS	Median	II,III,IV	0.856	0.710	<.001	33	view →
SARC	OS	Tertile	All	0.871	0.603	<.001	24	view →
LGG	OS	Quartile	All	0.813	0.935	<.001	21	view →
READ	DFS	Median	IV	0.398	0.796	.004	21	view →
SKCM	DFS	Median	All	0.675	0.835	.003	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PPARGC1A–MESO (OS)

Open the MESO breakdown →