PPARGC1A

Across TCGA pan-cancer cohorts, PPARGC1A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPARGC1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPARGC1A RNA is repressed in tumor relative to normal tissue. In most cancer types PPARGC1A is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where PPARGC1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPARGC1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.166	<.001	12	view →
COAD	Female	All	−1.948	<.001	12	view →
THCA	Male	III,IV	−3.981	<.001	11	view →
BLCA	All	All	−1.070	<.001	10	view →
HNSC	Male	All	−1.491	<.001	8	view →
LUAD	Female	II,III,IV	−1.358	<.001	8	view →
LUSC	All	II,III,IV	−1.220	<.001	8	view →
UCEC	All	All	−0.836	<.001	8	view →
LIHC	Male	II,III,IV	−1.745	<.001	6	view →
KIRP	Male	All	−0.989	.002	6	view →
BRCA	All	III,IV	−0.963	<.001	6	view →
READ	All	II,III,IV	−2.155	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPARGC1A–KIRC

Open the KIRC breakdown →