POLR3GL

Across TCGA patient cohorts, POLR3GL mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3GL-associated genes across cancer lineages are TRIM49B, RPL31P59, and MIR548AL. Each is linked with POLR3GL in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3GL-to-partner and partner-to-POLR3GL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM49B grouped by POLR3GL-low versus POLR3GL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3GL→partner) and Y-score (partner→POLR3GL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM49B →	+0.369	+3.188	<.001	.003	3	2
LUSC	RPL31P59 →	+0.182	+4.211	.003	.009	3	2
LUSC	MIR548AL →	+0.338	+5.081	<.001	.004	3	2
SKCM	RNA5SP31 →	+0.344	+7.816	<.001	.008	3	1
SKCM	WARS2P1 →	+0.144	+7.816	<.001	.008	3	1
UCEC	MIR6846 →	+0.816	+3.163	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

TRIM49B by POLR3GL expression — UCEC

Explore this box plot interactively →