POLR3GL

Across TCGA pan-cancer cohorts, POLR3GL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of POLR3GL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where POLR3GL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3GL is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where POLR3GL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3GL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.550	<.001	10	view →
KICH	Female	All	−1.530	<.001	9	view →
THCA	All	IV	−0.875	<.001	9	view →
LIHC	All	II,III,IV	+0.692	<.001	8	view →
LUSC	Male	II,III,IV	−0.718	<.001	7	view →
UCEC	All	All	−1.016	<.001	6	view →
BLCA	Male	III,IV	−0.901	.008	6	view →
BRCA	All	II,III,IV	−0.530	<.001	6	view →
COAD	Female	All	−0.573	<.001	5	view →
LUAD	Male	All	−0.348	.001	4	view →
PRAD	All	All	−0.435	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

POLR3GL–KIRC

Open the KIRC breakdown →