POLR3GL

Across TCGA pan-cancer cohorts, POLR3GL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated POLR3GL data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher POLR3GL RNA is associated with better overall survival. In most high-consensus cancer types, elevated POLR3GL expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, ACC, and KIRP are the cancer types where POLR3GL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.647	0.510	<.001	81	view →
ACC	DFS	Tertile	All	0.173	0.733	<.001	54	view →
KIRP	DFS	Median	IV	0.036	0.526	.006	48	view →
KIRC	DFS	Median	III,IV	0.774	0.504	<.001	44	view →
CESC	OS	Quartile	All	0.889	0.681	<.001	36	view →
LAML	DFS	Median	All	0.452	0.681	<.001	36	view →
SCLC	OS	Quartile	II,III,IV	0.452	0.832	.007	23	view →
SKCM	OS	Quartile	II,III,IV	0.499	0.192	.003	21	view →
HNSC	OS	Tertile	All	0.232	0.558	<.001	20	view →
UCEC	DFS	Tertile	III,IV	0.731	0.448	.017	18	view →
THCA	DFS	Median	All	0.908	0.775	.003	18	view →
READ	DFS	Quartile	III,IV	0.442	0.943	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

POLR3GL–BRCA (OS)

Open the BRCA breakdown →