POLR2J

Across TCGA patient cohorts, POLR2J mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible POLR2J-associated genes across cancer lineages are ARHGAP42P4, PPIAP56, and OR2V1. Each is linked with POLR2J in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR2J-to-partner and partner-to-POLR2J results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP42P4 grouped by POLR2J-low versus POLR2J-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2J→partner) and Y-score (partner→POLR2J) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP42P4 →	+0.031	+5.045	<.001	.009	3	1
BRCA	PPIAP56 →	+0.164	+5.096	<.001	.008	3	1
BRCA	OR2V1 →	+0.059	+4.995	.008	.009	3	1
BRCA	MAGEB5 →	+0.076	+5.971	<.001	.002	3	1
BRCA	MIR542 →	+0.435	+6.016	<.001	.002	3	1
BRCA	MIR605 →	+0.822	+5.575	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ARHGAP42P4 by POLR2J expression — BRCA

Explore this box plot interactively →