POLR2J

Across TCGA pan-cancer cohorts, POLR2J RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of POLR2J’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where POLR2J RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2J is over-expressed in tumor.

KIRC, KIRP, and COAD are the cancer types where POLR2J tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2J RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.854	<.001	12	view →
KIRP	All	IV	+1.245	<.001	11	view →
COAD	Female	II,III,IV	+0.569	<.001	10	view →
LIHC	Female	II,III,IV	+1.022	<.001	9	view →
HNSC	Male	III,IV	+0.983	<.001	9	view →
LUSC	Female	II,III,IV	+0.988	<.001	8	view →
LUAD	Female	III,IV	+0.902	<.001	8	view →
BLCA	All	All	+0.578	.003	7	view →
UCEC	All	All	+0.686	<.001	6	view →
BRCA	All	III,IV	+0.586	<.001	6	view →
STAD	All	All	+0.437	.001	6	view →
CHOL	Male	All	+1.248	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

POLR2J–KIRC

Open the KIRC breakdown →