POLR2J

Across TCGA pan-cancer cohorts, POLR2J RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated POLR2J data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher POLR2J RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2J expression acts as an unfavorable survival marker, although some lineages such as CHOL and THYM show a favorable association.

KIRC, UVM, and KICH are the cancer types where POLR2J RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.742	0.864	<.001	116	view →
UVM	OS	Median	All	0.439	0.842	<.001	107	view →
KICH	DFS	Median	III,IV	0.269	0.914	<.001	101	view →
ACC	DFS	Median	All	0.223	0.697	<.001	72	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
LGG	DFS	Tertile	All	0.622	0.801	<.001	36	view →
LIHC	OS	Median	III,IV	0.200	0.517	.001	22	view →
COAD	DFS	Tertile	II,III,IV	0.602	0.746	.013	17	view →
HNSC	DFS	Quartile	All	0.262	0.448	.007	13	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	10	view →
KIRP	DFS	Median	All	0.803	0.961	.020	10	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

POLR2J–KIRC (OS)

Open the KIRC breakdown →