POLQ

Across TCGA cell cohorts, POLQ mutation is significantly associated with the RNA expression of many other genes, with 1,957 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POLQ-associated genes across cancer lineages are CNTROB, LILRA1, and GSDMA. Each is linked with POLQ in more than 2 cancer types. Because this analysis shows association rather than direction, both POLQ-to-partner and partner-to-POLQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTROB grouped by POLQ-low versus POLQ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLQ→partner) and Y-score (partner→POLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNTROB →	+0.566	+2.222	<.001	.001	3	3
SOFT_TISSUE	LILRA1 →	+0.049	+3.515	.001	.003	3	2
SOFT_TISSUE	GSDMA →	+0.102	+3.321	.004	.005	3	2
PANCREAS	GLT6D1 →	+0.004	+4.029	<.001	.007	3	2
OESOPHAGUS	IFNK →	+0.031	+3.807	<.001	<.001	3	2
OESOPHAGUS	KRTAP29-1 →	+0.104	+3.115	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,957 associations by consensus.

CNTROB by POLQ expression — LARGE_INTESTINE

Explore this box plot interactively →