POLQ

Across TCGA pan-cancer cohorts, POLQ RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated POLQ data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher POLQ RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLQ expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

ACC, MESO, and KIRP are the cancer types where POLQ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.369	0.820	<.001	152	view →
MESO	OS	Median	All	0.249	0.524	<.001	147	view →
KIRP	OS	Tertile	All	0.414	0.729	<.001	128	view →
KIRC	DFS	Median	All	0.552	0.689	<.001	108	view →
KICH	DFS	Quartile	II,III,IV	0.327	1.000	<.001	105	view →
LIHC	DFS	Median	All	0.430	0.648	<.001	94	view →
PAAD	DFS	Tertile	All	0.159	0.475	<.001	60	view →
UCEC	DFS	Tertile	All	0.609	0.760	<.001	60	view →
LGG	OS	Median	All	0.722	0.900	<.001	54	view →
LUAD	DFS	Tertile	All	0.742	0.864	<.001	42	view →
THCA	DFS	Quartile	III,IV	0.417	0.819	.002	34	view →
SARC	OS	Median	All	0.413	0.753	<.001	29	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

POLQ–ACC (OS)

Open the ACC breakdown →