POLQ

Across TCGA pan-cancer cohorts, POLQ RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of POLQ’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where POLQ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLQ is over-expressed in tumor.

BLCA, HNSC, and COAD are the cancer types where POLQ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLQ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.272	<.001	12	view →
HNSC	Male	IV	+1.595	<.001	11	view →
COAD	Female	II,III,IV	+0.980	<.001	11	view →
KIRP	All	III,IV	+0.821	<.001	11	view →
KIRC	Male	All	+0.558	<.001	11	view →
LUAD	Male	III,IV	+1.693	<.001	9	view →
STAD	Female	All	+1.614	<.001	9	view →
LIHC	Female	II,III,IV	+0.726	<.001	9	view →
LUSC	Male	II,III,IV	+2.538	<.001	8	view →
UCEC	All	III,IV	+2.270	<.001	8	view →
BRCA	All	II,III,IV	+1.362	<.001	6	view →
THCA	All	III,IV	+0.213	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

POLQ–BLCA

Open the BLCA breakdown →