POLE4

Across TCGA patient cohorts, POLE4 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLE4-associated genes across cancer lineages are RNA5SP405, RNA5SP28, and RNU6-1329P. Each is linked with POLE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both POLE4-to-partner and partner-to-POLE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP405 grouped by POLE4-low versus POLE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLE4→partner) and Y-score (partner→POLE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP405 →	+0.443	+4.260	<.001	.007	3	1
UCEC	RNA5SP28 →	+1.316	+3.109	<.001	.007	3	1
UCEC	RNU6-1329P →	+0.316	+4.132	<.001	.009	3	1
UCEC	H3C15 →	+0.038	+4.069	<.001	.002	3	1
UCEC	HBZP1 →	+0.084	+4.727	<.001	.003	3	1
UCEC	RNU1-11P →	+0.865	+3.122	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

RNA5SP405 by POLE4 expression — UCEC

Explore this box plot interactively →