Q-omics provides the consensus-scored RNU1-11P profile across patient tissues and cancer cell-line models. RNU1-11P expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, RNU1-11P is differentially expressed in 7, with the highest sampling consensus in KICH. Additionally, RNU1-11P RNA expression shows 5,851 significant pathway-activity associations, with the highest sampling consensus in LGG. Together, these results highlight HNSC, KICH, and LGG as cancer lineages where RNU1-11P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU1-11P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU1-11P survival associations across molecular data types. RNU1-11P RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU1-11P RNA expression–survival associations across cancer types. High RNU1-11P expression shows unfavorable associations in KIRC, SARC, UCS and CHOL, but favorable associations in HNSC and STAD. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .006). Together, the overview and detailed table identify HNSC as the clearest survival context for RNU1-11P RNA expression.
This table summarizes RNU1-11P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for RNU1-11P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU1-11P shows higher tumor expression in KICH, ESCA, BRCA, STAD, COAD and THCA. The KICH box plot shows higher RNU1-11P RNA expression in tumor versus normal tissue (log2 FC = +0.097, t-test p = .011).
This table shows molecular features associated with RNU1-11P in patient tissues and cancer cell lines. In patient samples, RNU1-11P shows the broadest associations at the RNA and protein expression levels, with LGG recurring as the lineage with the largest associated feature set.
