POLE4

Across TCGA pan-cancer cohorts, POLE4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated POLE4 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher POLE4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated POLE4 expression acts as an unfavorable survival marker, although some lineages such as THCA and LUSC show a favorable association.

KICH, ACC, and HNSC are the cancer types where POLE4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.741	1.000	.001	107	view →
ACC	OS	Median	All	0.774	0.963	<.001	90	view →
HNSC	DFS	Median	III,IV	0.237	0.362	<.001	82	view →
KIRP	DFS	Quartile	All	0.331	0.801	<.001	62	view →
LIHC	OS	Median	All	0.436	0.701	<.001	45	view →
LUAD	DFS	Median	All	0.595	0.752	.001	45	view →
LGG	DFS	Median	All	0.322	0.477	<.001	33	view →
LAML	DFS	Median	All	0.417	0.717	.002	30	view →
UVM	DFS	Tertile	III,IV	0.168	1.000	.002	28	view →
UCEC	DFS	Tertile	All	0.783	0.886	.003	26	view →
THCA	DFS	Tertile	All	0.928	0.789	.003	25	view →
BLCA	OS	Tertile	All	0.339	0.558	.018	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

POLE4–KICH (OS)

Open the KICH breakdown →