POLE4

Across TCGA pan-cancer cohorts, POLE4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of POLE4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLE4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLE4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where POLE4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLE4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.168	<.001	12	view →
KIRC	Female	All	+0.443	<.001	10	view →
LIHC	All	II,III,IV	+0.543	<.001	6	view →
KICH	All	All	−0.555	.001	4	view →
CHOL	All	All	+0.889	<.001	3	view →
COAD	Female	II,III,IV	+0.324	.026	3	view →
LUSC	All	All	+0.255	.006	3	view →
ESCA	All	All	+0.621	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

POLE4–HNSC

Open the HNSC breakdown →