Across TCGA cell cohorts, PNMA8B mutation is significantly associated with the RNA expression of many other genes, with 432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PNMA8B-associated genes across cancer lineages are KRT6C, PNLIPRP1, and OR52K1. Each is linked with PNMA8B in more than 1 cancer types. Because this analysis shows association rather than direction, both PNMA8B-to-partner and partner-to-PNMA8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNMA8B→partner) and Y-score (partner→PNMA8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KRT6C →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	PNLIPRP1 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	OR52K1 →	+0.060	+5.000	<.001	.005	3	1
OESOPHAGUS	CLRN1 →	+0.024	+4.017	<.001	.007	3	1
OESOPHAGUS	SLC6A18 →	+0.051	+4.017	.002	.007	3	1
OESOPHAGUS	INSL5 →	+0.073	+4.392	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 432 associations by consensus.

Exploration

PNMA8B survival (RNA) · tumor vs normal (RNA) · all PNMA8B data types