Q-omics provides the consensus-scored PMS2P5 profile across patient tissues and cancer cell-line models. PMS2P5 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, PMS2P5 is differentially expressed in 6, with the highest sampling consensus in HNSC. Additionally, PMS2P5 protein abundance shows 22,393 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight MESO, HNSC, and LSCC as cancer lineages where PMS2P5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PMS2P5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PMS2P5 survival associations across molecular data types. PMS2P5 RNA expression shows survival associations in the most cancer types (21), followed by mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PMS2P5 RNA expression–survival associations across cancer types. High PMS2P5 expression shows unfavorable associations in MESO, LGG and ACC, but favorable associations in KIRC, READ and COAD. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify MESO as the clearest survival context for PMS2P5 RNA expression.
This table summarizes PMS2P5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for PMS2P5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PMS2P5 shows higher tumor expression in HNSC, LUAD, LUSC, BRCA, BLCA and LIHC. The HNSC box plot shows higher PMS2P5 RNA expression in tumor versus normal tissue (log2 FC = +0.546, t-test p < 0.001).
This table shows molecular features associated with PMS2P5 in patient tissues and cancer cell lines. In patient samples, PMS2P5 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, PMS2P5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT.
