PMS2P5

Across TCGA pan-cancer cohorts, PMS2P5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PMS2P5 data layer compared with 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PMS2P5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PMS2P5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

MESO, LGG, and ACC are the cancer types where PMS2P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.272	0.530	.003	76	view →
LGG	OS	Median	All	0.750	0.868	<.001	52	view →
ACC	DFS	Quartile	All	0.388	0.803	.002	45	view →
KIRC	DFS	Quartile	All	0.774	0.472	.001	30	view →
READ	DFS	Median	II,III,IV	0.636	0.394	.006	28	view →
HNSC	OS	Tertile	III,IV	0.519	0.219	.008	19	view →
COAD	OS	Tertile	All	0.797	0.574	.013	19	view →
PRAD	DFS	Median	All	0.909	0.958	.001	14	view →
GBM	OS	Median	All	0.536	0.273	.001	12	view →
CHOL	DFS	Tertile	III,IV	0.172	0.779	.024	9	view →
DLBC	OS	Median	All	1.000	0.803	.006	9	view →
BLCA	DFS	Quartile	II,III,IV	0.343	0.532	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PMS2P5–MESO (DFS)

Open the MESO breakdown →