PLXNB1

Across TCGA cell cohorts, PLXNB1 mutation is significantly associated with the RNA expression of many other genes, with 1,911 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNB1-associated genes across cancer lineages are UTF1, C16orf90, and CGRRF1. Each is linked with PLXNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLXNB1-to-partner and partner-to-PLXNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by PLXNB1-low versus PLXNB1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB1→partner) and Y-score (partner→PLXNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	2
URINARY_TRACT	C16orf90 →	+0.017	+4.087	<.001	.009	3	2
BLOOD_Leukemia	CGRRF1 →	+0.661	+3.470	<.001	.002	3	2
BLOOD_Leukemia	CCDC70 →	+0.074	+2.300	.001	.006	3	2
BLOOD_Leukemia	NEDD1 →	+0.791	+3.351	.002	.003	3	2
BLOOD_Leukemia	SLC16A14 →	+1.241	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

UTF1 by PLXNB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →