PLXNB1

Across TCGA pan-cancer cohorts, PLXNB1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PLXNB1 data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PLXNB1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLXNB1 expression acts as an unfavorable survival marker, although some lineages such as UVM and BLCA show a favorable association.

UVM, BLCA, and HNSC are the cancer types where PLXNB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.855	0.432	<.001	126	view →
BLCA	OS	Median	II,III,IV	0.552	0.344	.003	62	view →
HNSC	OS	Median	IV	0.439	0.236	.001	61	view →
KIRP	DFS	Median	All	0.960	0.858	<.001	59	view →
MESO	OS	Median	All	0.524	0.268	<.001	48	view →
LAML	DFS	Tertile	All	0.665	0.329	<.001	46	view →
ACC	DFS	Tertile	III,IV	0.103	0.726	.002	45	view →
BRCA	OS	Quartile	III,IV	0.749	0.310	<.001	44	view →
KIRC	DFS	Tertile	II,III,IV	0.376	0.618	.001	42	view →
LUAD	DFS	Median	IV	0.272	0.804	.006	24	view →
ESCA	OS	Tertile	III,IV	0.627	0.422	.023	17	view →
LIHC	DFS	Tertile	All	0.264	0.485	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PLXNB1–UVM (OS)

Open the UVM breakdown →