PLOD3

Across TCGA patient cohorts, PLOD3 mutation is significantly associated with the RNA expression of many other genes, with 5,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLOD3-associated genes across cancer lineages are CICP28, CDCA2, and RFC5. Each is linked with PLOD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLOD3-to-partner and partner-to-PLOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CICP28 grouped by PLOD3-low versus PLOD3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD3→partner) and Y-score (partner→PLOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CICP28 →	+0.030	+4.341	<.001	<.001	3	3
UCEC	CDCA2 →	+0.811	+2.369	<.001	<.001	3	3
UCEC	RFC5 →	+0.556	+1.680	<.001	<.001	3	3
UCEC	LMNB1 →	+0.609	+1.637	.001	.001	3	3
LUSC	RNA5SP158 →	+0.132	+3.435	<.001	.003	3	3
UCEC	RNU6ATAC17P →	+0.169	+2.087	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,105 associations by consensus.

CICP28 by PLOD3 expression — LUAD

Explore this box plot interactively →