PLOD3

Across TCGA cell cohorts, PLOD3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLOD3-associated genes across cancer lineages are OR10G2, TAS2R60, and ACTRT1. Each is linked with PLOD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLOD3-to-partner and partner-to-PLOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by PLOD3-low versus PLOD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLOD3→partner) and Y-score (partner→PLOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10G2 →	+0.023	+6.022	<.001	.001	3	2
LUNG_SCLC	TAS2R60 →	+1.253	+5.643	<.001	.002	3	2
BLOOD_Leukemia	ACTRT1 →	+0.038	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TRIM42 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

OR10G2 by PLOD3 expression — SKIN

Explore this box plot interactively →