PLEKHG2

Across TCGA patient cohorts, PLEKHG2 mutation is significantly associated with the RNA expression of many other genes, with 4,256 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG2-associated genes across cancer lineages are ACYP1, MIR4529, and VN1R90P. Each is linked with PLEKHG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG2-to-partner and partner-to-PLEKHG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACYP1 grouped by PLEKHG2-low versus PLEKHG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG2→partner) and Y-score (partner→PLEKHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACYP1 →	+0.309	+1.584	.003	.002	3	4
BRCA	MIR4529 →	+0.723	+4.639	<.001	.005	3	3
READ	VN1R90P →	+0.120	+5.039	<.001	.008	3	3
SKCM	SPRYD7P1 →	+0.014	+2.331	.007	.003	3	3
UCEC	TRIM73 →	+0.081	+1.998	<.001	<.001	3	3
UCEC	RPL23AP82 →	+0.295	+1.439	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,256 associations by consensus.

ACYP1 by PLEKHG2 expression — UCEC

Explore this box plot interactively →