PLEKHG2

Across TCGA pan-cancer cohorts, PLEKHG2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PLEKHG2 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PLEKHG2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEKHG2 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UVM, ACC, and UCS are the cancer types where PLEKHG2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.392	0.802	<.001	130	view →
ACC	DFS	Median	All	0.217	0.668	<.001	107	view →
UCS	DFS	Median	III,IV	0.612	0.225	<.001	96	view →
MESO	OS	Tertile	All	0.283	0.587	<.001	73	view →
KIRP	DFS	Tertile	All	0.785	0.922	.003	49	view →
LGG	DFS	Tertile	All	0.652	0.840	<.001	46	view →
HNSC	DFS	Median	II,III,IV	0.645	0.537	.007	41	view →
CESC	OS	Tertile	All	0.836	0.929	.006	34	view →
LIHC	OS	Quartile	All	0.679	0.823	.006	27	view →
THYM	OS	Median	All	1.000	0.710	<.001	23	view →
LUAD	DFS	Tertile	All	0.721	0.844	.001	23	view →
KIRC	DFS	Tertile	II,III,IV	0.427	0.682	.005	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PLEKHG2–UVM (DFS)

Open the UVM breakdown →