PLAA

Across TCGA patient cohorts, PLAA mutation is significantly associated with the RNA expression of many other genes, with 2,164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAA-associated genes across cancer lineages are RNU6-918P, RN7SL342P, and RPS14P7. Each is linked with PLAA in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAA-to-partner and partner-to-PLAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-918P grouped by PLAA-low versus PLAA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAA→partner) and Y-score (partner→PLAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-918P →	+0.334	+4.409	.008	.006	3	2
READ	RN7SL342P →	+0.245	+5.219	<.001	.006	3	2
READ	RPS14P7 →	+0.187	+5.925	<.001	.002	3	2
PRAD	RNA5SP463 →	+0.566	+5.469	<.001	<.001	3	2
UCEC	PINCR →	+0.235	+1.626	<.001	.005	3	2
UCEC	SEPTIN14P12 →	+0.237	+2.917	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,164 associations by consensus.

RNU6-918P by PLAA expression — CESC

Explore this box plot interactively →