PLAA

Across TCGA pan-cancer cohorts, PLAA RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PLAA’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PLAA RNA is repressed in tumor relative to normal tissue. In most cancer types PLAA is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where PLAA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.287	<.001	10	view →
LIHC	Female	II,III,IV	+0.829	<.001	9	view →
COAD	All	II,III,IV	+0.432	<.001	9	view →
HNSC	All	III,IV	+0.466	.006	8	view →
BRCA	All	II,III,IV	+0.391	<.001	6	view →
STAD	All	II,III,IV	+0.605	.010	4	view →
READ	All	All	+0.502	.003	4	view →
BLCA	All	All	+0.294	.015	3	view →
CHOL	All	All	+1.028	.001	2	view →
UCEC	All	II,III,IV	+0.597	.045	2	view →
LUAD	All	All	+0.171	.033	2	view →
ESCA	Female	All	+1.143	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PLAA–THCA

Open the THCA breakdown →