PLA2G3

Across TCGA cell cohorts, PLA2G3 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G3-associated genes across cancer lineages are H2BW1, ADAM30, and SLC35G3. Each is linked with PLA2G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G3-to-partner and partner-to-PLA2G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by PLA2G3-low versus PLA2G3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G3→partner) and Y-score (partner→PLA2G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	H2BW1 →	+0.072	+4.874	<.001	.002	3	1
BLOOD_Leukemia	ADAM30 →	+0.017	+5.569	<.001	.001	3	1
BLOOD_Leukemia	SLC35G3 →	+0.065	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR9K2 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR8D4 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR56A4 →	+0.006	+4.874	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

H2BW1 by PLA2G3 expression — BLOOD_Leukemia

Explore this box plot interactively →