PLA2G3

Across TCGA pan-cancer cohorts, PLA2G3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PLA2G3 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLA2G3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLA2G3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, KIRC, and KIRP are the cancer types where PLA2G3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.791	0.667	.001	95	view →
KIRC	OS	Tertile	All	0.832	0.892	.001	93	view →
KIRP	OS	Tertile	III,IV	0.228	0.781	<.001	47	view →
SKCM	OS	Quartile	All	0.694	0.824	<.001	39	view →
LGG	DFS	Tertile	All	0.648	0.793	<.001	37	view →
READ	DFS	Tertile	All	0.773	0.250	.002	28	view →
UCEC	DFS	Median	III,IV	0.850	0.736	.012	28	view →
PCPG	DFS	Quartile	All	0.726	0.924	<.001	27	view →
DLBC	DFS	Median	All	0.304	0.858	.001	18	view →
OV	DFS	Median	II,III,IV	0.416	0.343	.020	16	view →
LUAD	DFS	Quartile	All	0.467	0.245	.008	15	view →
THYM	DFS	Median	III,IV	0.471	1.000	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PLA2G3–HNSC (OS)

Open the HNSC breakdown →