PLA2G3

Across TCGA pan-cancer cohorts, PLA2G3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLA2G3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLA2G3 RNA is repressed in tumor relative to normal tissue. In most cancer types PLA2G3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where PLA2G3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.405	<.001	12	view →
KIRP	Male	II,III,IV	−0.496	<.001	11	view →
COAD	Female	All	+1.464	<.001	10	view →
LUAD	Male	III,IV	−2.306	<.001	9	view →
THCA	All	All	−0.432	<.001	8	view →
UCEC	All	All	+1.903	<.001	6	view →
HNSC	All	All	−0.961	.009	5	view →
BRCA	Female	All	+0.383	.003	4	view →
LUSC	Male	III,IV	−1.707	.016	3	view →
LIHC	All	All	+0.022	.013	3	view →
KICH	All	All	+0.610	.001	2	view →
PRAD	All	All	−0.552	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLA2G3–KIRC

Open the KIRC breakdown →