PIGB

Across TCGA patient cohorts, PIGB mutation is significantly associated with the RNA expression of many other genes, with 2,658 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGB-associated genes across cancer lineages are OR8I2, LCEP1, and MIR6780B. Each is linked with PIGB in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGB-to-partner and partner-to-PIGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8I2 grouped by PIGB-low versus PIGB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGB→partner) and Y-score (partner→PIGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR8I2 →	+0.054	+7.930	<.001	.008	3	2
LUAD	LCEP1 →	+0.079	+7.930	<.001	.008	3	2
BLCA	MIR6780B →	+0.399	+3.883	.009	.006	3	2
BLCA	RNU6-31P →	+0.455	+4.450	<.001	.002	3	2
UCEC	RNA5SP419 →	+0.378	+1.617	.003	.008	3	2
COAD	FAM242E →	+0.034	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,658 associations by consensus.

OR8I2 by PIGB expression — LUAD

Explore this box plot interactively →