PIGB

Across TCGA pan-cancer cohorts, PIGB RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PIGB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PIGB RNA is repressed in tumor relative to normal tissue. In most cancer types PIGB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where PIGB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.713	<.001	10	view →
KIRC	All	All	+0.403	<.001	10	view →
LIHC	Male	All	+0.696	<.001	9	view →
HNSC	All	All	+0.370	.001	8	view →
KICH	Female	All	−0.817	<.001	7	view →
CHOL	Female	All	+1.876	<.001	5	view →
STAD	Male	All	+0.382	.016	4	view →
BLCA	All	All	+0.359	.031	3	view →
LUAD	Male	II,III,IV	+0.523	.020	1	view →
READ	All	II,III,IV	+0.214	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PIGB–THCA

Open the THCA breakdown →