PIGB

Across TCGA pan-cancer cohorts, PIGB RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PIGB data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PIGB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGB expression acts as an unfavorable survival marker, although some lineages such as KIRC and SARC show a favorable association.

UVM, KIRC, and LGG are the cancer types where PIGB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.228	0.820	<.001	104	view →
KIRC	OS	Quartile	All	0.729	0.521	<.001	64	view →
LGG	OS	Median	All	0.743	0.868	<.001	40	view →
HNSC	OS	Quartile	All	0.288	0.605	.004	35	view →
SARC	OS	Median	All	0.887	0.787	.001	32	view →
BRCA	DFS	Median	III,IV	0.927	0.825	.008	27	view →
PAAD	DFS	Median	All	0.223	0.497	.004	26	view →
CESC	DFS	Median	All	0.458	0.620	.012	26	view →
GBM	DFS	Median	All	0.156	0.246	.003	17	view →
DLBC	DFS	Median	All	0.629	1.000	.017	14	view →
ESCA	DFS	Tertile	IV	0.216	0.692	.024	12	view →
UCS	DFS	Tertile	IV	0.975	0.482	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PIGB–UVM (DFS)

Open the UVM breakdown →