PHYHIPL

Across TCGA patient cohorts, PHYHIPL mutation is significantly associated with the RNA expression of many other genes, with 1,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHYHIPL-associated genes across cancer lineages are DEFB104A, TIMM9P1, and MTND6P8. Each is linked with PHYHIPL in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIPL-to-partner and partner-to-PHYHIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB104A grouped by PHYHIPL-low versus PHYHIPL-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIPL→partner) and Y-score (partner→PHYHIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DEFB104A →	+0.723	+5.010	<.001	.009	3	2
SKCM	TIMM9P1 →	+0.185	+3.564	<.001	.005	3	2
LUAD	MTND6P8 →	+0.170	+5.584	<.001	.002	3	2
LUSC	MIR1200 →	+0.797	+5.211	<.001	.007	3	2
SKCM	TCERG1L-AS1 →	+0.472	+3.050	.001	.008	3	2
UCEC	RNU6-23P →	+0.257	+1.867	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,668 associations by consensus.

DEFB104A by PHYHIPL expression — CESC

Explore this box plot interactively →