PHYHIPL

Across TCGA pan-cancer cohorts, PHYHIPL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PHYHIPL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PHYHIPL RNA is repressed in tumor relative to normal tissue. In most cancer types PHYHIPL is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where PHYHIPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHYHIPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−4.503	<.001	11	view →
THCA	Male	III,IV	−0.132	<.001	8	view →
LIHC	Male	II,III,IV	+2.637	<.001	7	view →
KIRC	Male	All	−0.963	<.001	6	view →
BRCA	Female	All	−0.537	<.001	6	view →
LUSC	All	All	+0.329	.001	3	view →
PRAD	All	All	−1.262	<.001	2	view →
LUAD	All	All	+0.308	.005	2	view →
CHOL	All	All	+1.793	.020	1	view →
KIRP	Female	All	+1.085	.022	1	view →
HNSC	All	III,IV	+0.182	.026	1	view →
ESCA	Female	All	−0.096	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PHYHIPL–KICH

Open the KICH breakdown →