Q-omics provides the consensus-scored PHF5GP profile across patient tissues and cancer cell-line models. PHF5GP expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, PHF5GP is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, PHF5GP RNA expression shows 14,473 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LUSC, KICH, and UVM as cancer lineages where PHF5GP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PHF5GP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PHF5GP survival associations across molecular data types. PHF5GP RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PHF5GP RNA expression–survival associations across cancer types. High PHF5GP expression shows unfavorable associations in UVM, DLBC and ESCA, but favorable associations in LUSC, STAD and KIRC. The LUSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for PHF5GP RNA expression.
This table summarizes PHF5GP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for PHF5GP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PHF5GP shows higher tumor expression in KICH, LUSC, COAD, UCEC, PRAD and LUAD. The KICH box plot shows higher PHF5GP RNA expression in tumor versus normal tissue (log2 FC = +0.170, t-test p < 0.001).
This table shows molecular features associated with PHF5GP in patient tissues and cancer cell lines. In patient samples, PHF5GP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
