Across TCGA patient cohorts, PGAM4 mutation is significantly associated with the RNA expression of many other genes, with 872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAM4-associated genes across cancer lineages are SNORA36A, RN7SL302P, and MIR6783. Each is linked with PGAM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGAM4-to-partner and partner-to-PGAM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM4→partner) and Y-score (partner→PGAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNORA36A →	+0.448	+3.868	.001	.002	3	3
BLCA	RN7SL302P →	+0.186	+5.038	<.001	.009	3	2
LUAD	MIR6783 →	+0.934	+4.882	<.001	<.001	3	2
HNSC	MTCO1P44 →	+0.134	+7.954	<.001	.008	3	2
HNSC	MIR6760 →	+0.403	+7.954	<.001	.008	3	2
SKCM	SERPINE4P →	+0.244	+3.310	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 872 associations by consensus.

Exploration

PGAM4 survival (RNA) · tumor vs normal (RNA) · all PGAM4 data types