PFDN2

Across TCGA patient cohorts, PFDN2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PFDN2-associated genes across cancer lineages are OFD1P11Y, RNU6-458P, and IGHVIII-82. Each is linked with PFDN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFDN2-to-partner and partner-to-PFDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OFD1P11Y grouped by PFDN2-low versus PFDN2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFDN2→partner) and Y-score (partner→PFDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
HNSC	RNU6-458P →	+0.308	+7.954	<.001	.008	3	1
COAD	IGHVIII-82 →	+0.231	+4.790	<.001	.006	3	1
UCEC	RNU6-103P →	+0.539	+5.031	<.001	.009	3	1
UCEC	MIR218-1 →	+0.883	+4.982	<.001	.009	3	1
UCEC	MIR607 →	+0.612	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OFD1P11Y by PFDN2 expression — SKCM

Explore this box plot interactively →