Q-omics provides the consensus-scored IGHVIII-82 profile across patient tissues and cancer cell-line models. IGHVIII-82 expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in CESC. Additionally, IGHVIII-82 RNA expression shows 4,606 significant pathway-activity associations, with the highest sampling consensus in KIRC. Together, these results highlight CESC, and KIRC as cancer lineages where IGHVIII-82 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes IGHVIII-82 survival associations across molecular data types. IGHVIII-82 RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

IGHVIII-82 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	CESC (72)	view →

This table ranks reproducible IGHVIII-82 RNA expression–survival associations across cancer types. High IGHVIII-82 expression shows unfavorable associations in CESC, UCS, ESCA, READ, COAD and THCA. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .007). Together, the overview and detailed table identify CESC as the clearest survival context for IGHVIII-82 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.156	0.759	.007	72	view →
UCS	OS	Tertile	III,IV	0.104	0.591	.004	72	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
READ	DFS	Tertile	All	0.183	0.605	.002	24	view →
COAD	OS	Tertile	II,III,IV	0.282	0.614	.006	21	view →
THCA	DFS	Tertile	II,III,IV	0.145	0.794	.001	18	view →

Pink = unfavorable, green = favorable. all 7 lineages →

IGHVIII-82-CESC (OS)

Kaplan–Meier survival curve for IGHVIII-82 RNA expression in CESC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with IGHVIII-82 in patient tissues and cancer cell lines. In patient samples, IGHVIII-82 shows the broadest associations at the RNA and protein expression levels, with KIRC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	4,606	KIRC (3030)	view →
RNA	3,339	UCEC (848)	view →