IGHVIII-82

Across TCGA pan-cancer cohorts, IGHVIII-82 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGHVIII-82 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGHVIII-82 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVIII-82 expression acts as an unfavorable survival marker.

UCS, CESC, and ESCA are the cancer types where IGHVIII-82 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.104	0.591	.004	72	view →
CESC	OS	Tertile	II,III,IV	0.156	0.759	.007	72	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
READ	DFS	Tertile	All	0.183	0.605	.002	24	view →
COAD	OS	Tertile	II,III,IV	0.282	0.614	.006	21	view →
THCA	DFS	Tertile	II,III,IV	0.145	0.794	.001	18	view →
SARC	DFS	Tertile	All	0.081	0.632	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHVIII-82–UCS (OS)

Open the UCS breakdown →