Q-omics provides the consensus-scored MIR218-1 profile across patient tissues and cancer cell-line models. MIR218-1 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in LUSC. Among the 18 cancer types available for tumor–normal comparison, MIR218-1 is differentially expressed in 2, with the highest sampling consensus in KICH. Additionally, MIR218-1 RNA expression shows 9,135 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight LUSC, KICH, and LUAD as cancer lineages where MIR218-1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR218-1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR218-1 survival associations across molecular data types. MIR218-1 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR218-1 RNA expression–survival associations across cancer types. High MIR218-1 expression shows unfavorable associations in LUSC, COAD, THYM, ACC and LIHC, but favorable associations in PAAD. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .014). Together, the overview and detailed table identify LUSC as the clearest survival context for MIR218-1 RNA expression.
This table summarizes MIR218-1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for MIR218-1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR218-1 shows higher tumor expression in KICH and THCA. The KICH box plot shows higher MIR218-1 RNA expression in tumor versus normal tissue (log2 FC = +0.413, t-test p < 0.001).
This table shows molecular features associated with MIR218-1 in patient tissues and cancer cell lines. In patient samples, MIR218-1 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.
