Across TCGA pan-cancer cohorts, MIR218-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MIR218-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MIR218-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIR218-1 is over-expressed in tumor.

KICH and THCA are the cancer types where MIR218-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIR218-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	+0.413	<.001	6	view →
THCA	All	All	+0.106	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: MIR218-1 RNA expression & survival · all MIR218-1 data types